Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1996-05-03
1999-09-14
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
562466, 562469, 562473, A61K 3119, C07C 6206
Patent
active
059523824
ABSTRACT:
Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ailments manifesting an overregulation of RAR receptors and/or a hypervitaminosis A.
REFERENCES:
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patent: 5574036 (1996-11-01), Bernardon et al.
J. Pharm. Belg., 1994, 221-5, Shroot et al.
Biochem. Biophys. Res. Commun, 1992, 977-83, Bernard et al.
Lee et al, Proc. Natl. Acad. Sci., USA, 91:5632-5636 (1994).
Lee et al., J. Biol. Chem., 271(20):11897-11903 (1996).
Yoshimura et al, J. Med. Chem., 38:3163-3173 (1995).
Aulakh Charanjit S.
Centre International de Recherches Dermatologiques Galderma
Rotman Alan L.
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