Adamantyl-substituted polycyclic acetylene compounds and pharmac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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424 69, 514569, 514828, 514844, 514845, 514846, 514847, 514848, 514859, 514861, 514863, 514871, 514912, 544154, 546322, 549 79, 549454, 560255, 562451, 562466, 562467, 564172, 568439, 568609, 585352, A61K 3119, A61K 31535, C07C 6364, C07D295112

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055740367

ABSTRACT:
Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

REFERENCES:
Chemical Abstracts, vol. 87, No. 3, Jul. 18, 1977, Columbus, Ohio; abstract No. 22693b, Musantaeva, SH. et al, "Synthesis of P-Acetylenybenzoic Acid", p. 599, col. 2; & Deposited doc., 1974, pp. 297-75, Viniti.

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