Adamantyl substituted oxindoles as pharmaceutical agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544333, 544405, 544238, 544295, 544296, 544182, 544180, 544179, 544357, 544373, 546186, 546187, 546256, 5462777, 514241, 514242, 514253, 514316, 514323, 514333, 514339, C07D40106, C07D40114, A61K 3144, A61K 31505

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active

059487810

ABSTRACT:
This invention relates to a method of treating cancer by administering a compound of the formula wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E.sup.1, E.sup.2, p, Het' and Het" are defined as indicated in the specification.

REFERENCES:
patent: 4760083 (1988-07-01), Myers et al.
Graham, "Inhibitors of Protein Farnesylation: A New Approach to Cancer Chemotherapy," Exp. Opin. Ther. Patents, vol. 5, No. 12, pp. 1269-1285, 1995.
Nagasu et al., "Inhibition of Human Tumor Xenograft Growth by Treatment with the Farnesyl Transferase Inhibitor B956," Cancer Research, vol. 55, pp. 5310-5314, 1995.

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