Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2011-06-28
2011-06-28
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S218000, C514S237800, C514S252120, C514S307000, C514S462000, C540S575000, C544S165000, C544S400000, C546S146000, C549S336000, C564S182000, C564S133000
Reexamination Certificate
active
07968601
ABSTRACT:
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1and R2each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alkyloxy; or R1and R2taken together with the carbon atom with which they are attached form a C3-6cycloalkyl; and where n is 2, either R1or R2may be absent to form an unsaturated bond; R3represents a C6-12cycloalkyl, preferably selected from cylo-octanyl and cyclohexyl or R3represents a monovalent radical having one of the following formulae wherein said C6-12cycloalkyl or monovalent radical may optionally be substituted with one, or where possible two, three or more substituents selected from the group consisting of C1-4alkyl, C1-4alkyloxy, halo or hydroxy; Q represents Het1or Ar2wherein said C3-8cycloalkyl, Het1or Ar2are optionally substituted with one or where possible two or more substituents selected from halo, C1-4alkyl, C1-4alkyloxy, hydroxy, nitro, NR5R6, C1-4alkyloxy substituted with one or where possible two, three or more substituents each independently selected from hydroxycarbonyl, Het2and NR7R8, and C1-4alkyl substituted with one or where possible two or three halo substituents, preferably trifluoromethyl; R5and R6each independently represent hydrogen, C1-4alkyl, or C1-4alkyl substituted with phenyl; R7and R8each independently represent hydrogen or C1-4alkyl; R9and R10each independently represent hydrogen, C1-4alkyl or C1-4alkyloxycarbonyl; L represents C1-4alkyl; Het1represents a heterocycle selected from pyridinyl, thiophenyl, or 1,3-benzodioxolyl; Het2represents piperidinyl, pyrrolidinyl or morpholinyl; Ar2represents phenyl, naphtyl or indenyl.
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PCT International Sear
Buyck Christophe Francis Robert Nester
Gilissen Ronaldus Arnodus Hendrika Joseph
Jaroskova Libuse
Linders Joannes Theodorus Maria
Van der Veken Louis Jozef Elisabeth
Chu Yong
Janssen Pharmaceutica N.V.
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