Adamantane derivatives with neuroprotective, antidepressant...

Details Adamantane derivatives with neuroprotective, antidepressant... Adamantane derivatives with neuroprotective, antidepressant...

2006-12-05

2006-12-05

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S230000, C514S631000, C514S634000

Reexamination Certificate

active

07145037

ABSTRACT:
The invention describes compounds represented by the general formula (I) given below:in which:n is an integer between 1 and 4;R1and R2are chosen independently from hydrogen and a methyl group;R3is chosen independently from a linear, branched or cyclic alkyl group containing from 1 to 3 carbon atoms (R3a) and a simple amino group (R3b) or an amino group substituted with a nitro group (R3c) The compounds are useful for treating central nervous system diseases or peripheral neuropathies.

REFERENCES:
patent: 4007181 (1977-02-01), DuCharme et al.
patent: 5061703 (1991-10-01), Bormann et al.
patent: 2002/0028836 (2002-03-01), Altenbach et al.
patent: 1 943 404 (1970-12-01), None
patent: 1 274 652 (1972-05-01), None
patent: WO 91/18868 (1991-12-01), None
patent: WO 99/20599 (1999-04-01), None
patent: WO 99/31051 (1999-06-01), None
patent: WO 99/38841 (1999-08-01), None
patent: WO 99/42458 (1999-08-01), None
patent: WO 02/070468 (2002-09-01), None
patent: WO 03/024401 (2003-03-01), None
Westland et al, J. med Chem., 1972, vol. 15, No. 12, 1313-1321.
Database Chemcats Online Chemical Abstracts Service., Columbus, Ohis, US; XP002305001, retrieved from STN Databse Accession No. 2001:2447512 RN 313376-00-0 & “Pharma Library Collection (Catalog)” Apr. 24, 2003, Ordre No. NS64016.
Novakov, I.A., et al, Khim.Farm. Zh., Supplied by British Library—“The World's Knowledge” www.bl.uk 1987, pp. 454-458, vol. 21(4).
Bernatowicz, M.S., et al., 1H-Prazole-1carboxamidine Hydrochlorine: An Attractive Reagent for Guanylation of Amines and Its Application to Peptide Synthesis, J. Org. Chem. Soc., 1992, pp. 2497-2502, vol. 57.
McKay, A.F., The Preparation of N-Substituted-N1-nitroguanidines by the Reaction of Primary Amines with N-Alkyl-N-nitroso-N1-nitroguanidines1, J. Am. Chem. Soc., Contribution from the Departement of Chemistry, Queens University, 1949, pp. 1968-1970, vol. 71.
Foster et al., The Novel Anticonvulsant MK-801 Binds to the Activated State of the N-methyl-D-aspartate Receptor in Rat Brain, Br. J. Pharmacol. 1987, pp. 403-409, vol. 91.
Zablocka et al., PAF Antagonist, BN52021, Inhibits [3H]D-Aspartate Release After Ischaemia in Vitro NeuroReport 6, 1994, vol. 6, No. 1, pp. 85-88.
Berenbaum et al, Insulin-Like Growth Factors Counteract the Effect of Interleukin 1β on Type II Phospholipase A2 Expression and Arachidonic Acid Release by Rabbit Articular Chondrocytes, FEBS Letters, 1994, vol. 340, pp. 51-55.
Green et al., Analysis of Nitrate, Nitrite, and [15N]Nitrate in Biological Fluids, Analytical Biochemistry, 1982, vol. 126, pp. 131-138.
Porsolt et al., Behavioural Despair in Mice: A Primary Screening Test for Antidepressants, Arch. Int. Pharmacodyn. 1977, vol. 229, pp. 327-336; and.
Steru et al., The Tail Suspension Test: A New Method for Screening Antidepressants in Mice, Psychopharmacology 1985, vol. 85, pp. 367-370.

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