Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2009-03-30
2011-12-13
Kumar, Shailendra (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S354000, C514S355000, C514S448000, C514S461000
Reexamination Certificate
active
08076372
ABSTRACT:
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
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Goel, A., et al., “Benzamide-Based Thiolcarbamates: A New Class of HIV-1 NCp7 Inhibitors,” Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, pp. 767-770.
Song, Y., et al., “Synthesis and Biological Properties of Amino Acid Amide Ligand-Based Pyridinioalkanoyl Thioesters as Anti-HIV Agents,” Bioorganic & Medicinal Chemistry, 2002, vol. 10, pp. 1263-1273.
Turpin, et al., “Synthesis and Biological Properties of Novel Pyridinioalkanoyl Thiolesters (PATE) as Anti-HIV-1 Agents That Target the Viral Nucleocapsid Protein Zinc Fingers”,J. Med. Chem. (1999) 42:67-86.
Appella Ettore
Goel Atul
Inman John K.
Schito Marco
Turpin Jim A.
Cantor & Colburn LLP
Government of the United States
Kumar Shailendra
LandOfFree
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