Acylquinolinone derivatives, and antiallergic preparations and m

Details Acylquinolinone derivatives, and antiallergic preparations and m Acylquinolinone derivatives, and antiallergic preparations and m

1982-03-19

1984-10-09

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546155, 546156, 544 94, 560 19, 560 44, 562458, 564199, 564414, 548485, 548486, A61K 3147, C07D21522

Patent

active

044761325

ABSTRACT:
Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.B together with R.sub.C and also R.sub.D together with R.sub.E represent an additional bond in each case, or, when R.sub.2 represents a radical R.sub.4, R.sub.B and R.sub.C together represent an additional bond and R.sub.3 and R.sub.D together represent oxo and R.sub.E represents a radical R.sub.5, and their salts, have antiallergic properties. They are manufactured, for example, by subjecting a compound of the formula (IV) ##STR2## in which Z represents a removable radical, or a tautomer and/or salt thereof, to intramolecular cyclisation.

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