Acyloxymethylcarbamate prodrugs of oxazolidinones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S215000, C548S225000, C548S229000, C514S374000

Reexamination Certificate

active

10937187

ABSTRACT:
The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.

REFERENCES:
patent: WO97/09328 (1997-03-01), None
Folkman, Michael and Frantz J. Lund; “Acyloxymethyl Carbonochloridates. New Intermediates in Prodrug Synthesis,” Synthesis, 1990, pp. 1159-1166.
Mulvihilli, Mark J., et. al., “Synthesis and Application of Novel Glyoxylate-derived Chloroformates,” Synthesis, 2002, pp. 365-370.
Rautio, Jarkko, et. al., “Synthesis and In Vitro Evaluation of Aminoacyloxyalkyl Esters of 2-(6-methoxy-2-naphthyl) propionic Acid as Novel Naproxen Prodrugs for Dermal Drug Delivery,” Pharmaceutical Research, vol. 16, No. 8, 1999, pp. 1172-1178.
Wheeler, W.J., et. al., Journal of Medicinal Chemistry, vol. 22, No. 6, 1979, pp. 657-661.

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