Acyloxyisopropyl carbamates as prodrugs for amine drugs

Details Acyloxyisopropyl carbamates as prodrugs for amine drugs Acyloxyisopropyl carbamates as prodrugs for amine drugs

1994-12-13

1997-11-04

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514487, 546188, 558271, 558272, 558273, 560 29, 560 32, 560 33, A61K 31455, A61K 3127, C07D21140, C07D27116

Patent

active

056840187

ABSTRACT:
This invention relates to novel acyloxyisopropyl carbamates as bioreversible prodrug moieties for amino drugs and to methods of synthesizng these compounds.

REFERENCES:
patent: 4760057 (1988-07-01), Alexander
patent: 4916230 (1990-04-01), Alexander
Miyauchi et al., Chem. Pharm. Bull.; 38, pp. 1077-1078 (1990).
Saari et al., J. Med. Chem.; 27, pp. 713-717 (1984)).
Sakamoto et al., Chem. Pharm. Bull.; 33, pp. 4870-4877 (1985).

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