Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Details Acyloxyalkyl carbamate prodrugs, methods of synthesis and use Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

2007-11-27

2007-11-27

Zucker, Paul A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C546S279400, C548S530000, C549S068000, C549S484000, C560S024000

Reexamination Certificate

active

11508131

ABSTRACT:
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

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