(Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moi

Details (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moi (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moi

1985-04-22

1988-07-26

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142345, 5142352, 5142358, 5142375, 514254, 514299, 514306, 514314, 514320, 514330, 514338, 514341, 514342, 514365, 514394, 514396, 514479, 514481, 514484, 514488, 544121, 544135, 544358, 544363, 544365, 546112, 546153, 546156, 546158, 546165, 546167, 546200, 548146, 548181, 548201, 548204, 560 19, 560 24, 560 30, 560 31, 560 32, 560 51, 560161, 560162, 560163, 560167, 560165, C07C12504, A61K 31495, A61K 31555, C07D40110

Patent

active

047600578

ABSTRACT:
This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function thereon. Hydrolytic enzymes are used to trigger the regeneration of the parent amine drug of the carbamate prodrug moiety. The case also contains pharmaceutical composition, method of treatment and process claims.

REFERENCES:
patent: 4156784 (1979-05-01), Dockner et al.
patent: 4292317 (1981-09-01), Pesson
patent: 4522819 (1985-06-01), Fox, Jr. et al.
patent: 4544747 (1985-10-01), Ishikawa et al.
L. G. Agood, Journal of Medicinal Chemistry, 13, 1176 (1970).

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