Acylmercaptoalkanoylamino and mercaptoalkanoylamino benzazepines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514213, 540461, 540523, A61K 31395, A61K 3155, C07D22316, C07D22506

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active

057234574

ABSTRACT:
Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus are useful as cardiovascular agents.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4192945 (1980-03-01), Ondetti
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4409146 (1983-10-01), Thorsett
patent: 4410520 (1983-10-01), Watthey
patent: 4415496 (1983-11-01), Harris et al.
patent: 4460579 (1984-07-01), Karanewsky
patent: 4465679 (1984-08-01), Huang et al.
patent: 4470988 (1984-09-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 4477464 (1984-10-01), Slade et al.
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4537885 (1985-08-01), Watthey
patent: 4539150 (1985-09-01), Katakami et al.
patent: 4548932 (1985-10-01), Sugihara et al.
patent: 4575503 (1986-03-01), Watthey
patent: 4584294 (1986-04-01), Ruyle
patent: 4587050 (1986-05-01), Harris et al.
patent: 4587238 (1986-05-01), Harris et al.
patent: 4594341 (1986-06-01), Cheung et al.
patent: 4617301 (1986-10-01), Patchett et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4680392 (1987-07-01), Harris et al.
patent: 4699905 (1987-10-01), Yangisawa et al.
patent: 4711884 (1987-12-01), Karanewsky
patent: 4734410 (1988-03-01), Yanagisawa et al.
patent: 4749688 (1988-06-01), Haslanger
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4873235 (1989-10-01), Parsons et al.
patent: 4963539 (1990-10-01), Delaney
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5075302 (1991-12-01), Neustadt
patent: 5098934 (1992-03-01), Vevert et al.
patent: 5190974 (1993-03-01), Clemence et al.
patent: 5208236 (1993-05-01), Neustadt
patent: 5223516 (1993-06-01), Delaney
patent: 5225401 (1993-07-01), Seymour
patent: 5232920 (1993-08-01), Neustadt
patent: 5238924 (1993-08-01), Smith
patent: 5262436 (1993-11-01), Haslanger et al.
patent: 5362727 (1994-11-01), Robl
patent: 5366973 (1994-11-01), Flynn et al.
patent: 5532359 (1996-07-01), Marsters, Jr.
Boyer, T.D. "Cirrhosis of the Liver and Its Major Sequelae", in: Wyngaarden, J.B., et al., Cecil Textbook of Medicine, vol. 1 (Philadelphia, Saunders Co., 1992), pp. 786-789.
Robl, J.A. et al. Bioorg. Med. Chem. Lett. 4, 1795-1800 (1994).
Robl et al., Biiorganic & Medicinal Chem. Letters, vol. 4, pp. 1795-1800, 1994, month of publication not provided.
Dussaule et al., Jour. of Clinical Endocrinology and Metabolism, vol. 72, pp. 653-659, 1991, month of publication not provided.
Loffi et al., Gastroenterology, vol. 96, pp. 167-177, 1989, month of publication not provided.
Fyhrquist et al., The Lancet, Dec. 21/28, 1985, p. 1439, month of publication not provided.
Fernandez-Cruz, The Lancet, Dec. 21/28, 1985, pp. 1439-1440, month of publication not provided.
Naming and Indexing of Chemical Substances for Chemical Abstracts, 1987 Index Guide, Section 203, month of publication not provided.
Watthey et al., J. Med. Chem., 28, pp. 1511-1516 (1985). Publication month not provided.
Slade et al., J. Med. Chem., 28, pp. 1517-1521 (1985). Publication month not provided.
Thorsett et al., J. Med. Chem., 29, pp. 251-260 (1986). Publication month not provided.
Yanagisawa et al., J. Med. Chem., 30, pp. 1984-1991 (1987). Publication month not provided.
Yanagisawa et al., J. Med. Chem., 31, pp. 422-428 (1988). Publication month not provided.
Parsons et al., Biochem and Biophysical Research Comm. 117, pp. 108-113 (1993). Publication month not provided.
Atwood et al., FEBS Letters, vol. 165, pp. 201-206 (1984). Publication month not provided.
Natoff et al., Drugs Of the Future, vol. 12, pp. 475-483 (1987). Publication month not provided.
Itoh et al., Chem. Pharm. Bull., vol. 34, pp. 1128-1147 and 2078-2089 (1986). publication month not provided.
Flynn, Tetrahedron Letters, vol. 31, pp. 815-818 (1990). publication month not provided.
Thorsett, Actual Chim. Ther., vol. 13, pp. 257-268 (1986). publication month not provided.
Atwood et al., J. Chem. Soc. Perkin Trans I (1986) pp. 1011-1019. publication month not provided.
Robl, Tetrahedron Letters, vol. 35, pp. 393-396 and 1393-1396, (1994). publication month not provided.
Delaney et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1783-1788 (1994). publication month not provided.
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1789-1794 (1994). publication month not provided.
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2055-2060 (1994). publication month not provided.
Das et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2193-2198 (1994). publication month not provided.
Bolos et al., J. Org. Chem., 57, 3535-3539 (1992). publication month not provided.
Bolos et al., Tetrahedron, vol. 48, pp. 9567-9576 (1992). publication month not provided.
Adams et al., Synthetic Communications, vol. 18, 2225-2231 (1988). publication month not provided.
Chackalamannil et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, pp. 1003-1006 (1992). publication month not provided.
Flynn et al., J. Med. Chem., 36, pp. 2420-2423 (1993) publication month not provided.
Robl et al., J. Am. Chem. Soc., 116, pp. 2348-2355 (1994). publication month not provided.
Karanewsky et al, Chemical Abstract 122:81350 for CA 2096460 (Nov. 19, 1993).

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