Acylindole derivatives and their use in pharmaceutical compositi

Details Acylindole derivatives and their use in pharmaceutical compositi Acylindole derivatives and their use in pharmaceutical compositi

1986-10-16

1987-11-24

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548493, C07D20912, A61K 3140

Patent

active

047089610

ABSTRACT:
The present invention is concerned with novel acylindole derivatives of the formula (I) and platelet-aggregation inhibiting agents containing them as an active ingredient. ##STR1## In the formula (I), either R.sub.1 and R.sub.2 is hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkyl group substituted by at least one hydroxy group and having 1 to 5 carbon atoms, or a group of the formula ##STR2## in which R.sub.3 is an alkyl group having 1 to 5 carbon atoms, and --OR.sub.2 is a substituent at the ortho or para position.
The compounds of the invention are useful as preventive medicine or remedy for various diseases or symptoms caused by platelet-aggregation, as well as inhibitors of platelet-aggregation on vascular walls during or after an operation.

REFERENCES:
Chemical Abstracts, vol. 82, No. 21, p. 85, No. 133482y, May 26, 1975.
Chemical Abstracts, vol. 83, No. 7, p. 421, No. 58569X, Aug. 18, 1975.
Tetrahedron Letters, vol. 22, No. 47, pp. 4751-4754, 1981.
Journal of the Chemical Society, Part I, pp. 625-628 (1957).
Powell et al, Chemical Abstracts, vol. 96, No. 142006n, 1982.

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