Acylimine cephalosporins

Details Acylimine cephalosporins Acylimine cephalosporins

1975-09-23

1977-08-09

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2602391, 544 24, 544 27, 544 28, 544 29, 544 30, C07D50116, C07D49902, C07D50104, C07D49904

Patent

active

040410293

ABSTRACT:
A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypochlorite. Finally, a defined reagent is added yielding a side chain on the carbon adjacent to the amino-nitrogen. Novel intermediate compounds are also described. The end compounds prepared are active against both gram-positive and gram-negative bacteria.

REFERENCES:
patent: 3778432 (1973-12-01), Pines
patent: 3994885 (1976-11-01), Koppel

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