Acylhydrazone derivatives and the use thereof in the...

Details Acylhydrazone derivatives and the use thereof in the... Acylhydrazone derivatives and the use thereof in the...

2008-07-29

2008-07-29

Powers, Fiona T (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S563000, C514S615000, C560S136000, C562S439000, C564S148000

Reexamination Certificate

active

10574781

ABSTRACT:
The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: R1and R5independently of one another represent H, OH, OA, OAc or methyl; R2, R3, R4, R6, R7, R8, R9and R10independently of one another represent H, OH, OA, OAc, OCF3, Hal, NO2, CF3, A, CN, OSO2CH3, SO2CH3, NH2, or COOH; R11represents H or CH3; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH2, CH2CH2, OCH2or —CH(OH)— and Hal represents F, Cl, Br or I.

REFERENCES:
patent: 2003/0225126 (2003-12-01), Markham et al.
patent: 2004/0038882 (2004-02-01), Lang et al.
patent: 2004/0110963 (2004-06-01), Burri et al.
patent: 101 49 393 (2003-04-01), None
patent: 0 294 258 (1988-12-01), None
patent: 0 889 127 (1999-01-01), None
patent: 11-106371 (1999-04-01), None
patent: WO 00/62781 (2000-10-01), None
patent: WO-01/70213 (2001-09-01), None
patent: WO 01/70213 (2001-09-01), None
patent: WO 02/17893 (2002-03-01), None
patent: WO 02/070464 (2002-09-01), None
patent: WO 02/074987 (2002-09-01), None
Dilanyan et al., Chemical Abstracts, 125:212091, 1996.
Kotali et al., Chemical Abstracts, 125:275360, 1996.
Pandeya et al., Acta Pharmaceutica (Zagreb, Croatia), 53(1), 15-24, 2003.
Muanprasat et al., Journal of General Physiology, 124(2), 125-137, Aug. 2004.
Pandeya et al., Pharmazie, 56(2), 121-124, 2001.
Issa et al., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 31(1), 95-105, 2001.
XP-001205216 ; Pandeya et al. ; “Design of semicarbazones and their bio-isosteric analogues as potential anticonvulsants”; Pharmazie vol. 56, 2001; pp. 121-125.
XP-002316513; Chemcats—ChemStar Product List; Apr. 2003: pp.1-4; accession No. 2000:911593.
XP-002316522; Beilstein Registry #3324432; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1-2.
XP-002316521; Beilstein Registry #2381518; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1.
XP-002316520; Beilstein Registry #3365109; Beilstein Institut zur Foerderung der Chemischen Wissenschaften; 1988-2003; pp. 1.
XP-002316519; STN CA Caesar accession No. 1165; pp. 1.
XP-002316518; STN CA Caesar accession No. 1135; pp. 1.
XP-002316517; STN CA Caesar accession No. 1163; pp. 1.
XP-002316516; STN CA Caesar accession No. 1142; pp. 1-2.
XP-002316515; STN CA Caesar accession No. 1167; pp. 1-2.
XP-002316514; 1/6—(c) File Chemcats; accession No. 2001:2460460; pp. 1-4.

Affiliated with

Also associated with

Rating

Acylhydrazone derivatives and the use thereof in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acylhydrazone derivatives and the use thereof in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acylhydrazone derivatives and the use thereof in the... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3905375