Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-04-03
2000-09-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
51421206, 5142295, 5142305, 540300, 540301, 540521, 544 89, 544 95, A61K 315365, A61K 3155, C07D49804
Patent
active
061242780
ABSTRACT:
Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.
REFERENCES:
patent: 5426192 (1995-06-01), Baumann et al.
patent: 5650409 (1997-07-01), Rogers et al.
patent: 5736543 (1998-04-01), Rogers et al.
patent: 5747492 (1998-05-01), Lynch et al.
Johnstrom Peter
Rogers Gary A.
Coleman Henry D.
Raymond Richard L.
Sudol R. Neil
The Regents of the University of California
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