Acylation process for the synthesis of HMG-CoA reductase inhibit

Details Acylation process for the synthesis of HMG-CoA reductase inhibit Acylation process for the synthesis of HMG-CoA reductase inhibit

1987-04-15

1989-07-04

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 584, 544 69, 544149, 544229, 544374, 546 14, 546206, 546207, 548406, 548517, 549292, C07F 718

Patent

active

048452378

ABSTRACT:
A novel acylation process using an alkali metal bromide and a dialkylaminopyridine to form a sterically hindered ester functionality from an alkanoyl chloride and an alcohol is disclosed.

REFERENCES:
patent: 4661483 (1987-04-01), Hoffman et al.
H. M. R. Hoffmann, K. Haase, Synthesis, 715 (1981).
Chemical Abstracts, 72, 42844, 42845W (1970).
S. D. Saraf and M. Zaki, Synthesis, 612 (1973).

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