Acylation of amino acids

Details Acylation of amino acids Acylation of amino acids

1977-03-28

1978-11-21

Douglas, Winston A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 560159, 560169, 562561, C11C 300, C07C10352, C07C10124, C07C10126

Patent

active

041266285

ABSTRACT:
N-mono-substituted derivatives of diamino acids are prepared by the reaction of succinimidyl esters of carboxylic acids or substituted carbonic acids with the unprotected diamino acid. The acylation preferentially occurs at the side chain or terminal amino group of the diamino acid. For example, selective acylation of the terminal amino group of lysine occurs without first having protected the 2-amino group. Such acylation has application in the preparation of inter alia N.sup.6 -palmitoyl-lysine.

REFERENCES:
patent: 3317559 (1967-05-01), Anderson
patent: 3541084 (1970-11-01), Hagitani et al.
patent: 3578641 (1971-05-01), Johnson
patent: 3780015 (1973-12-01), Hirschmann et al.
patent: 3870694 (1975-03-01), Fujino et al.
patent: 3880823 (1975-04-01), Hagitani et al.
patent: 4043992 (1977-08-01), Fujimoto et al.
Anderson et al., "JACS" , vol. 86, pp. 1839-1842 (1964).

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