Acylation of a lactone-substituted aniline compound in the absen

Details Acylation of a lactone-substituted aniline compound in the absen Acylation of a lactone-substituted aniline compound in the absen

1979-03-08

1980-09-23

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603473, 2603475, C07D33324, C07D30768, C07D30712

Patent

active

042244536

ABSTRACT:
A process for making a compound of the formula ##STR1## which process comprises contacting, in the absence of an acid acceptor, an acyl halide with an aniline substituted gamma-butyrolactone in the presence of a non-basic solvent and at a temperature between 65.degree. and 150.degree. C. Thus, 3-(N-chloroacetyl-N-2,6-dimethylphenylamino)-gamma-butyrolactone is prepared by a process comprising contacting, in the absence of an added acid acceptor, chloroacetylchloride with 3-(N-2,6-dimethylphenylamino)-gamma-butyrolactone in the presence of a non-basic organic solvent and at a temperature between 65.degree. and 150.degree. C. Preferably, the 3-(N-2,6-dimethylphenylamino)-gamma-butyrolactone is formed by reacting alpha-bromo-gamma-butyrolactone with dimethylaniline in the presence of water and in a non-basic organic solvent, and the 3-(N-2,6-dimethylphenylamino)-gamma-butyrolactone in the organic solvent is phase separated and fed straight through to the acetylation step.

REFERENCES:
patent: 3933860 (1976-01-01), Chan

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