Acylated vincaminic acid derivatives

Details Acylated vincaminic acid derivatives Acylated vincaminic acid derivatives

1988-09-02

1989-11-28

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D46100, A61K 31475

Patent

active

048838764

ABSTRACT:
Vincaminic acid derivatives represented by the formula ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkoxyalkyl group having 2 to 6 carbon atoms, R.sup.2 is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a halogenated alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxycarbonylallyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, a phenyl group, a phenyl group substituted by alkoxy groups each having 1 or 2 carbon atoms or a thienyl group, A is a hydroxy group, B is a hydrogen atom, or A and B together form a valence bond, and the acid addition salts thereof are disclosed. These compound are useful as thereapeutic effect on cerebovascular injuries.

REFERENCES:
patent: 4001251 (1977-01-01), Najer et al.
patent: 4146643 (1979-03-01), Pfaffli
Lewin et al., Heterocycles, vol. 14, No. 12, pp. 1915-1920 (1980).

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