Acylated pyrimidine nucleosides for treatment of systemic inflam

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 49, A61K 3170, C07H 19067

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active

056913206

ABSTRACT:
Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.

REFERENCES:
patent: 3868451 (1975-02-01), Stein et al.
patent: 4613604 (1986-09-01), Chu et al.
patent: 4757139 (1988-07-01), Kawaguchi et al.
patent: 4874602 (1989-10-01), Calabresi et al.
Aderka et al., "Med Hypotheses", (1988), 27:193-6.
Arai M. et al, "Hepatology" (1989) 9:846-851.
Bowers et al., "J. Surg. Res." (1989) 47:183-8.
Cerra et al, in "Molecular and Cellular Mechanisms of Septic Shock" 265-277, Alan R. Liss (1989).
Clark et al., "Am. J. Pathol." (1987), 129:192-9.
Echtenacher et al, "J. Immunol." 145:3762-3766 (1990).
Engelhardt, R. et al, "Cancer. Res." (1991), 51:2524-30.
Farrar and Corwin, Ann. "N.Y. Acad. Sci." 133:668-684 (1966).
Galanos et al, "PNAS", 76:5939-5943, (1979).
Gut et al, "J. Infect. Disease." (1984) 149:621.
Halacheva et al., "Toxicon" (1988), 26:571-576.
Havell, "J. Immunol." 139:4225-4231 (1987).
Kang et al., "J. Histochem. Cytochem." (1988), 36:665-678.
Kilpatrick et al, "Metabolism" (1989) 38:73-7.
Kimura et al, "Cancer, Chemother, Pharmacol" (1987); 20:223-9.
Lomanto et al, "Anesth. Analg." (1972), 51:264-270.
Markley et al, "J. Trauma" 10:598-607, (1970).
McClain CJ and Cohen DA, "Hepatology" (1989) 9:349-351.
Nolan JP, "Gastroenterology" 69:1346-1356 (1975).
Nolan, JP, "Hepatology" (1989), 10:887-91.
Nolan JP and Leibowitz AI, "Gastroenterology" (1978), 75:445-9.
O'Sullivan, "Aust. N.Z. J. Med.", (1973) 3:417-422.
Pappo et al, "J. Surg. Res." (1991) 51:106-12.
Pates et al., "Farmakol Toksikol" (1968), 31:717-719.
Rosenthal et al, "Toxicology" 56:239-251 (1989).
Seljelid, "Scand. J. Immunol." (1989), 29:181-92.
Shafer et al "Gastroenterology" (1961), 40:782-784.
Shirai et al "Acta Pathol. Jpn." (1987) 37:1127-1134.
Taki et al "Eur. Surg. Res." (1985), 17:140-9.
Tiegs et al "J. Clin. Invest." (1992) 90:196-203.
Van Bladel et al "Cytokine" (1991) 3:149-54.
van Groeningen et al "Proceedings of the AACR" (1987), 28:195.
Van Groeningen et al "Cancer Tret Rep." (1986), 70:745-50.
Viens et al "J. Immunother" (1992), 11:218-24.
Von Euler et al "J. Biol. Chem." (1963), 238:2464-2469.
Wang et al "Arch. Surg." (1991), 126:219-224.
Lehninger, Albert L., "Biochemistry" Second Edition, Worth Publishers, Inc. New York, 1975, pp. 735-736.
Martin et al., J. Pharm. Sci., V. 76, No. 2 (Feb. 1987) pp. 180-183 "Synthesis And Antiviral Activity of Various Esters of
Casida et al, Biochemical Pharmacology, V. 15, (1966) pp. 627-644 "3',5'-Diesters of 5-Fluoro-2'-Deoxyuridine and Thymidine: Hydrolysis by Esterases in Human, Mouse, and Insect Tissue."
Ensminger et al, Biochemical Pharmacology, V. 28 (1979) pp. 1541-1545 "Thymidine 5'-O-Pivaloate: a Prodrug Derivative of Thymidine with Potential Applications in High-Dose Methotrexate Therapy."
Martin et al, Cancer Research, V. 42 (Oct. 1982) pp. 3964-3970 "High-Dose 5-Fluorouracil with Delayer Uridine `Rescue` in Mice."

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