Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1997-11-25
1999-09-07
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530331, 514 18, 514851, C07K 500
Patent
active
059488867
ABSTRACT:
This invention relates to acylated enol derivatives of .alpha.-ketoesters and .alpha.-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors in their own right and are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema.
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Burkhart Joseph P.
Mehdi Shujaath
Peet Norton P.
Delacroix-Muirheid C.
Gupta Balaram
Hoechst Marion Roussel Inc.
Tsang Cecilia J.
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