Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1997-07-02
1999-05-18
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
514 58, 514181, 514213, 514947, A61K9/70;31/715
Patent
active
059049294
ABSTRACT:
A pharmaceutical composition for trans-mucosal or transdermal administration wherein a per-C.sub.2-18 acylated cyclodextrin is used as a drug reservoir or carrier. The composition can be used safely and exhibits excellent drug release behavior.
REFERENCES:
patent: 5633368 (1997-05-01), Hirsenkorn
Chemical Abstracts 118:197895e (Kawahara et al), 1993.
Chemical Abstract 124:59731w (Hirenkorn) (From EP 678,525; Oct. 1995), 1996.
Matsubara, K., et al., Controlled Release of the LHRH Agonist Buserelin Acetate from Injectable Suspensions Containing Triacetylated Cyclodextrins in an Oil Vehicle, J. of Controlled Release, 31 (1994) pp. 173-180.
Uekama, K., et al., Peracylated B-Cyclodextrins as Novel Sustained-Release Carriers for a Water-Soluble Drug, Molsidomine, J. of Phar. Pharmacol. (1994) 46, pp. 714-717.
Hirayama F., et al., Enhanced Bioavailability and Reduced Metabolism of Salbutamol by Perbutanoyl-B-Cyclodextrin After Oral Administration in Dogs, Pharmaceutical Sciences (1995), vol. 1, pp. 517-520.
Hirayama, F., et al., Characterization of Peracylated B-Cyclodextrins with Different Chain Lengths as a Novel Sustained Release Carrier for Water-Soluble Drugs, Chem. Pharm. Bulletin 43 (1995) pp. 130-136.
Hirayama Fumitoshi
Kondo Akira
Kunihiro Haruo
Ohta Masaaki
Okamoto Yasuhiro
Appollina Mary A.
Janssen Pharmaceutica N.V.
Schenkman Leonard
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