Acylated aminoalkanimidazoles and - triazoles

Details Acylated aminoalkanimidazoles and - triazoles Acylated aminoalkanimidazoles and - triazoles

1995-05-16

1997-04-22

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514397, 5462751, 5483151, 5483381, A61K 31415, C07D40112, C07D40912, C07D23361

Patent

active

056229828

ABSTRACT:
The invention concerns azole compounds of formula ##STR1## wherein the substituents have various significances, in free form or salt form.
They can be prepared e.g. by acylation, or by aziridine or oxazole ring opening.
The compounds can be used as pharmaceuticals, especially as selective inhibitors of the 25-hydroxyvitamin D3--hydroxylases in the treatment of disorders of proliferation and differentiation in vitamin D--responsive tissues.

REFERENCES:
patent: 3796704 (1974-03-01), Metzger et al.
patent: 4191767 (1980-03-01), Warner, Jr. et al.
European Patient Office Patent Abstracts JP4005287 --Sep. 1, 1992 --Page 1 of 1.
Chem. Abstract 108:21901 vol. 108, 1988 --2 pages.

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