Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-08
1997-03-11
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514422, 514323, 5142352, 514253, 548496, 548468, 546201, 544143, 544373, C07D20920, C07D40306, C07D40106, C07D41306, A61K 3405, A61K 3445, A61K 31535, A61K 31495
Patent
active
056101775
ABSTRACT:
Novel acylated amino acids which are antagonists of endothelin are described. Methods for their preparation and pharmaceutical compositions containing them are also included. The compounds are expected to be useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, diabetes, head injury, and stroke.
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Doherty Annette M.
Hamilton Harriet W.
Kaltenbronn James S.
Quin, III John
Anderson Elizabeth M.
Springer David B.
Warner-Lambert & Company
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