Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-06
2007-11-06
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S195000
Reexamination Certificate
active
11035803
ABSTRACT:
This invention discloses and claims a compound conforming to the general formula (I):Wherein R1, R2, R′2, R3, R4and R5are as described herein. The compounds of the present invention exhibit an inhibitory effect on the production of β-amyloid peptide (β-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.
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patent: WO 98/22430 (1998-05-01), None
Pallàs et al., Current Pharmaceutical Design, (2006), 12(33), pp. 4389-4408.
Jeffrey N. Higaki et al., A Combinatorial Approach To The Identification Of Dipeptide Aldehyde Inhibitors of beta-Amyloid Production, J. Med. Chem. (1999, pp. 3889-3898, vol. 42).
Baltzer Sylvie
Dorsselaer Viviane Van
Schoentjes Bruno
Gupta Balaram
Sanofi-Aventis
Stockton Laura L.
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