Acylaminoheteroaryl hepatitis C virus protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S018700, C530S317000, C530S331000

Reexamination Certificate

active

07605126

ABSTRACT:
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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P. Ettmayer et al. J. Med. Chem. (2004) 47(10), pp. 2393-2404.
B. Testa. Biochem. Pharm. (2004) 68, pp. 2097-2106.

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