Acylamino mitosanes

Details Acylamino mitosanes Acylamino mitosanes

1983-12-23

1987-02-10

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548414, C07D48714, A61K 3140

Patent

active

046423524

ABSTRACT:
7-Acylamino-9a-methoxymitosanes having enhanced capacity to inhibit animal tumors in vivo relative to mitomycin C are produced by N.sup.7 -acylation of 7-amino-9a-methoxymitosane, or N.sup.1a,N.sup.7 -diacylation thereof. Carboxamide, thiocarboxamide, urea, thiourea, urethane, thiophosphoramide, phosphoramide, and sulfonamide derivatives are disclosed.

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