Acylamino imidazoles

Details Acylamino imidazoles Acylamino imidazoles

1974-09-11

1976-05-25

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424273, C07D23392

Patent

active

039593053

ABSTRACT:
Compounds of the formula (II): ##SPC1##
wherein R.sub.1 is an aliphatic moiety of 1-12 carbon atoms, a cycloaliphatic moiety of 3-7 carbon atoms or said aliphatic moiety or said cycloaliphatic moiety substituted by halogen, carboxylic acid, esterified carboxylic acid, carboxamide, nitro, hydroxyl, etherified hydroxyl, acylated hydroxyl, amino, alkylamino, dialkylamino or acylated amino: R.sub.2 is a hydrocarbon of 1-7 carbon atoms: R.sub.3 is amino, lower alkylamino, di-lower alkylamino, anilino or lower alkoxyl; R.sub.4 is hydrogen, R.sub.5 or CO.R.sub.5 wherein R.sub.5 is a hydrocarbon of 1-7 carbon atoms, are useful for their anti-inflammatory activity.

REFERENCES:
hoskinson Aust. J. Chem., 1968, Vol. 21, pp. 1913-1919.
Ichikawa et al., J. Heterocyclic Chem., 1965, Vol. 2, pp. 253-255.
Kulev et al., I. Chem. Abst., 1960, Vol. 54, column 11000.
Kulev et al., II Zhur. Obshchei Khim., 1959, Vol. 29, pp. 2401-2403.
Koroleva et al., Chem. Abst., 1962, Vol. 57, column 14594.
Montgomery et al., J. Org. Chem., 1959, Vol. 24, pp. 256-257.

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