Acyl guanidines as beta-secretase inhibitors

Details Acyl guanidines as beta-secretase inhibitors Acyl guanidines as beta-secretase inhibitors

2006-06-20

2009-11-03

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S314000, C514S372000, C514S378000, C514S406000, C544S140000, C546S176000, C548S214000, C548S248000

Reexamination Certificate

active

07612069

ABSTRACT:
There is provided a series of substituted acyl guanidines of Formula (I)or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4and R5as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

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