Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-11-23
2000-01-04
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514351, 514364, 514399, 514403, 514423, 514454, 514617, 514619, 514634, 546332, 548125, 5483365, 5483751, 548537, 549433, 549441, 549467, 564161, 564166, 564230, 564237, A61K 3134, A61K 3144, A61K 31165, C07D30779, C07C23362
Patent
active
060110597
ABSTRACT:
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R.sup.5 wherein R.sup.5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, and where X is N, R.sup.1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.
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Ahmad Saleem
Atwal Karnail S.
Dugar Sundeep
Wu Shung C.
Bristol--Myers Squibb Company
Huang Evelyn Mei
Rodney Burton
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