Acyl guanidine sodium/proton exchange inhibitors and method

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514351, 514364, 514399, 514403, 514423, 514454, 514617, 514619, 514634, 546332, 548125, 5483365, 5483751, 548537, 549433, 549441, 549467, 564161, 564166, 564230, 564237, A61K 3134, A61K 3144, A61K 31165, C07D30779, C07C23362

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active

060110597

ABSTRACT:
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R.sup.5 wherein R.sup.5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, and where X is N, R.sup.1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.

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patent: 5336689 (1994-08-01), Weber et al.
patent: 5733934 (1998-03-01), Ramakrishna
patent: 5756535 (1998-05-01), Schwark et al.
patent: 5814654 (1998-09-01), Kitano
patent: 5852046 (1998-12-01), Lang

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