Acyl derivatives of rapamycin

Details Acyl derivatives of rapamycin Acyl derivatives of rapamycin

1980-08-25

1982-02-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

546 90, A61K 3574, C07D49114

Patent

active

043168850

ABSTRACT:
Disclosed are monoacyl and diacyl derivatives of rapamycin, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are useful, inter alia, as antifungal antibiotics.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993992 (1975-12-01), Sehgal et al.
Vezina et al., Journal of Antibiot., vol. 28, pp. 721-726 (1975).
Sehgal et al., Journal of Antibiot., vol. 28, pp. 727-732 (1975).
Neil et al., Canadian Journal of Chem., vol. 56, pp. 2491-2492 (1978).
Baker et al., Journal of Antibiot., vol. 31, pp. 539-545 (1978).
Martel et al., Canadian Journal of Physiol., vol. 55, pp. 48-51 (1977).

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