Acyl derivatives of oxazolorifamycins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540457, 540458, 540459, 540468, C07D49818, A61K 31495

Patent

active

051807181

ABSTRACT:
The invention relates to novel acyl derivatives of rifamycins of the formula ##STR1## and the salts thereof, in which the structural elements --A.sub.1 --A.sub.2 --, --A.sub.3 --A.sub.4 -- and --A.sub.5 --A.sub.6 -- each denote ethylene or vinylene or the elements --A.sub.1 --A.sub.2 -- and --A.sub.3 --A.sub.4 -- each denote ethylene and --A.sub.5 --A.sub.6 -- denotes vinylene; X represents >C(R.sub.6)-- or >N-- and R.sub.6 denotes hydrogen or alkyl; alk denotes an aliphatic hydrocarbon radical; R.sub.1 denotes hydrogen or acyl; R.sub.2 denotes acyl, or alkyl which is optionally substituted by an aromatic radical, and R.sub.3 and R.sub.3 ' represent a common bond, or R.sub.3 denotes hydrogen or acyl, and R.sub.3 ' is hydrogen; R.sub.4 denotes hydrogen, cycloalkyl or aryl; R.sub.5 denotes hydrogen or acetyl; R.sub.7 denotes hydrogen or alkyl, which can be used as active compounds in medicaments, the preparation and use thereof, and pharmaceutical products and the preparation thereof.

REFERENCES:
patent: 4005077 (1977-01-01), Bickel et al.
patent: 4585589 (1986-04-01), Malabarba et al.
patent: 4876258 (1989-10-01), Kump et al.
patent: 4916126 (1990-04-01), Traxler et al.
patent: 4918066 (1990-04-01), Kump
patent: 5003070 (1991-03-01), Kump et al.
patent: 5053510 (1991-10-01), Kump
patent: 5100894 (1992-03-01), Taylor et al.
Chem. Abstract 87, 193990a (1977).
Chem. Abstract 75, 3809e (1977).
Traxler et al. J. Med. Chem. 33, 552 (1990).
Taguchi et al. Chem. Pharm. Bull. vol. 33 No. 5 pp. 2133-2136 (1985).
Kump et al. Chem. Abstr. vol. 111 (19) entry 173911m (1989) abstracting EP 314,624.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Acyl derivatives of oxazolorifamycins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acyl derivatives of oxazolorifamycins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acyl derivatives of oxazolorifamycins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-102199

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.