Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-09-21
2000-02-01
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 45, 514 49, 514917, A61K 3170, C07H 19073, C07H 19173
Patent
active
060203226
ABSTRACT:
The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
REFERENCES:
patent: 3585188 (1971-06-01), Marumoto et al.
patent: 3894000 (1975-07-01), Wechter et al.
patent: 3975367 (1976-08-01), Gish et al.
patent: 3991045 (1976-11-01), Ishida et al.
patent: 4048432 (1977-09-01), Baker
patent: 4208406 (1980-06-01), Lapinet et al.
patent: 4560678 (1985-12-01), Ranson
patent: 4657896 (1987-04-01), Yano et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4757139 (1988-07-01), Kawaguchi et al.
patent: 4758553 (1988-07-01), Ogoshi
patent: 4868162 (1989-09-01), Kawaguchi
patent: 5246708 (1993-09-01), Von Borstel et al.
Chemical Abstracts, vol. 74, No. 112368K, Rajabalee, Angew. Chem. Int. Ed. Engl. 10(1):75 (1971).
Rosowsky et al, "Cancer Treatment Reports" 65:93-99 (Jan./Fed. 1981).
Kanazir et al, Bull. Inst. Nuc. Sci. "Boris, Kidrich" 9:145-153 (1959).
Beltz et al, Bioch. Biophys. Acta 297:258-267 (1973).
Hunting, D.J., et al, Carcinogenesis 6:1525-1528 (1985).
Golba, et al, Int. J. Rad. Biol. 13:261-268 (1967).
Goh et al, Proc. Soc. Exp. Biol. Med. 145:938-943 (1974).
Horikawa, et al, Exp. Cell Res. 34:198-200 (1964).
Pantic, et al, Nature 193:993-994 (1962).
Paoletti, et al, Rev. Francais, Etudes Clin. et Bio. 9:950-955 (1964).
Petrovic, et al, Int. J. Radiat. Biol. 18:243-258 (1970).
Petrovic, et al, Studia Biophysica 43:13-18 (1974).
Petrovic, et al, Int. J. Radiat. Res. 11:609-611 (1967).
Savkovic et al, Nature 203:1297-1298 (1964).
Savkovic et al, Nature 211:1179-1180 (1966).
Savkovic et al, Int. J. Rad. Biol. 9:361-368 (1965).
Smets, et al, Int. J. Rad. Biol. 13:269-273 (1967).
Soska et al, Folia Biologica 5:190-198 (1959).
Sugahara et al, Brookhaven Symposia in Biology, 284-302 (1967).
Wagner, Int. J. Rad. Biol. 12:101-112 (1967).
Wilczok et al, Int. J. rad. Biol. 9:201-211 (1965).
Goyanes-Villaescusa et al, Lancet 2:575-576 (1973).
Dumont, Ann. Surg. 150:799-807 (1959).
Nicolau et al, Der Hautartz, 17:512-515 (1966).
Marshak et al, Proc. Soc. Exp. Biol. Med. 58:62-63 (1945).
Newman et al, Am. J. Physiol. 164:251-253 (1951).
Casida et al, Biochemical Pharmacology 15:627-644 (1966).
Hackh's Chemical Dictionary 3rd ed. Julius Grant, ed. pp. 44, 45, 332, 333.
Ensminger et al, Biochemical Pharmacology, 28: 1541-1545 (1979) thymidine 5'0-pivaloate.
Ensminger et al, the Chemical Abstracts, 92: 87921x (1980).
Narang et al, the Chemical Abstracts, 83:147700a (1975).
Adamiak et al, Chemical Abstracts, 106: 156803g (1987).
Pfleiderer, the Chemical Abstracts, 107: 218016j (1987).
Nair et al, the Chemical Abstracts, 101: 192382z (1984).
Ishido et al, the Chemical Abstracts, 92: 59149h (1980).
Fridovich, Annu. Rev. Biochem., 44:147-159 (1975).
Biochemistry, vol. 13, No. 3, Jan. 29th, 1974, pp. 553-559; M.J. Robins et al: "3'-0-aminoacyl-2'-deoxyadenosines and 2'-0-aminoacyl-3'-deoxyadenosines related to charged transfer ribonucleic acid termini".
Biochemistry, vol. 14, No. 14, Jul. 15th, 1974, pp. 3144-3151; S.P. Dutta et al: Synthesis and properties of the naturally occurring N-[(9-beta-D-ribofuranosylpurin-6-yl)-N-methylcarbamoyl]-L-threonine (mt6A) and other related synthetic analogs.
Biochemistry, vol. 20, No. 1, Jan. 6th, 1981, pp. 8-15, American Chemical Society: A. Bhuta et al: "Stereochemical control of ribosomal peptidyltransferase reaction. Role of amino acid side-chain orientation of acceptor substrate".
Biochemistry, vol. 20, No. 12, Jun. 9th, 1981, pp. 3480-3485, American Chemical Society; K. Quiggle et al: "Donor Site of Ribosomal Peptidyltransferase: Investigation of Substrate specificity using 2'(3')-0-(N-acylaminoacyl)dinucleoside phosphates as models of the 3'terminus of N-acylaminoacyl transfer ribonucleic acid".
Journal of American Chemical Society, vol. 104, No. 2, 1982, pp. 544-547, American Chemical Society; G. Buchi et al: "Photochemical epoxidation of aflatoxin B1 and sterigmatocystin: Synthesis of Guanine-Containing adducts".
Pure and Applied Chemistry, vol. 52, No. 12, 1980, pp. 2705-2715, IUPAC GB; T. Matsuura et al: "Organic Chemical Approach to Photo-Cross-Links of Nucleic Acids to Proteins".
Journal of Carbohydrate Nucleosides. Nucleotides, vol. 4, No. 6, 1977, pp. 387-408, Marcel Dekker, Inc.; E.K. Ryu et al; "Aminoacyl Derivatives of Nucleosides, Nucleotides, and Polynucleotides. XXVII. General Synthesis of 2'(3')-O-Aminoacyl Dinucleoside Phosphates Derived from the AA-tRNA terminus".
Morrison and Boyd, Fourth Edition, "Organic Chemistry", Allyn and Bacon, Inc., Boston, 1983.
Leukemia, 2(10) 109-110 (1988).
Blood, 74(6) 1923-1928 (1989).
Cancer Treatment Reports, 69(7-8), 851-857 (1985).
Bamat Michael Kevin
von Borstel Reid Warren
Kunz Gary L.
Pro-Neuron, Inc.
LandOfFree
Acyl deoxyribonucleoside derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acyl deoxyribonucleoside derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acyl deoxyribonucleoside derivatives and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-937633