Acyl CoA:cholesterol acyltransferase (ACAT-2)

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S300000, C530S344000, C514S002600, C514S008100, C435S007710, C435S015000, C435S069200

Reexamination Certificate

active

10779251

ABSTRACT:
Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.

REFERENCES:
patent: 5484727 (1996-01-01), Chang et al.
patent: 5834283 (1998-11-01), Chang et al.
patent: 5968749 (1999-10-01), Chang et al.
patent: 6100077 (2000-08-01), Sturley et al.
patent: 6444876 (2002-09-01), Lassner et al.
patent: 6579974 (2003-06-01), Cases et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 6869937 (2005-03-01), Cases et al.
patent: 7045326 (2006-05-01), Cases et al.
patent: 2002/0170091 (2002-11-01), Lassner et al.
patent: 2003/0059420 (2003-03-01), Grabowski et al.
patent: 2003/0096772 (2003-05-01), Crooke et al.
patent: 2004/0230050 (2004-11-01), Cases et al.
patent: 2005/0256033 (2005-11-01), Hayden et al.
patent: WO 94/09126 (1994-04-01), None
patent: WO 99/67368 (1994-09-01), None
patent: WO 97/45439 (1997-12-01), None
Parini et al, Circulation, 2004, 110:2017-2023.
Kovacs et al, Society for Neuroscience Abstract Viewer and Itinerary Planner, 2003, Abstract #336.7, abstract only.
Hutter-Paier et al, Neuron, 2004, 44:227-238.
Du et al, JBC, 2004, 279/45:47010-47016.
Miyazaki et al, Current Opinion in investigational Drugs, 2003, 4/9:1095-1099, abstract only.
Zhao et al, Neuroscience Letters, 2005, 388/1:17-20, abstract only.
Sturley, Current Opinion in Lipdology, 1997, 8:167-173.
Tanaka, et al. J. Med. Chem, 41: 2390-2410, 1998.
Tanaka, et al. Bioorganic and Medicinal Chem. Letters, 8:81-86, 1998.
Tanaka, et al. Bioorganic and Medicinal Chemistry, 6:15-30, 1998.
Roth, DDT, 3/1:19-25, 1998.
Nicolosi, et al, Atherosclerosis, 137:77-85, 1998.
Dugar, et al. Bioorganic and Medicinal Chemistry, 3/9:1231-1236, 1995.
Wilson, et al., J. Lipid Research, 35:943-955, 1995.
Suckling et al., J. Lipid Research, 26: 647-671, 1985.
White et al., J. Medicinal Chem., 39:3908-3919, 1996.
Buhman et al., BBA, 1529:142-154, 2000.
Krause et al., Arterioscler. Thromb., 14:598-604, 1994.
Chang et al., JBC, 268/28:20747-20755, 1993.
Buhman et al, Nature Medicine, 6/12:1341-1347, 2000.
Accad et al, J. Clin. Invest. 105:711-719.
Change et al., JBC, 275/36:28083-92.
Uelmen et al, JBC, 270/44:26192-16201, 1995.
Farese, Current Opinion in Lipidology, 9:119-123, 1998.
Izem, et al., Biochem. J., 329:81-89, 1998.
Cases et al., JBC, 273/41:26755:764, 1998.
Roark et al., J. Med. Chem. 36:1662-1668, 1993.
Erickson et al., Metabolism 29/10:991-996.
Chang et al., JBC, 273/52:35132-141, 1998.
Oelkers et al., JBC, 273/41:26765-26771, 1998.
Anderson et al., JBC, 273/41-: 26747-26754, 1998.
Meiner et al., JBC, 273/2:1064-1069, 1998.
Meiner et al., PNAS (USA), 93:14041-14046, 1996.
Davignon, Diabete and Metabolisme (Paris), 21:139-146, 1995.
Lee et al., Bioorganic and Med. Chem. Letters, 8:289-294, 1998.
Matsuda, Medicinal Research Reviews, 14/3:271-305, 1994.
Matsuda et al., BBA, 1301:76-94, 1996.
O'Brien et al., J. Med. Chem., 39:2354-2366, 1996.
Vaccaro et al., J. Med. Chem., 39:1704-1719, 1996.
Wang et al., Arteriocler. Thromb. Vasc. Biol., 16:809-814, 1996.
Chang et al., Ann. Rev. Biochem. 66:613-638, 1997.
Jungquero et al., Biochemical Pharmacology, 61: 387-398, 1997.
Burnett et al., Clinic Chimica Acta, 286:231-242, 1999.
Tanaka et al., J. Med. Chem., 41:4408-4420, 1998.
Sellers et al., Toxicol. Sci., 46: 151-154, 1998.
Rudel et al., Current Opinion in Lipidology, 12:121-127, 2001.
Rudel et al., Nature Medcine, 6/12:1313-1314, 2000.
Cao et al., JBC, 271/24:14642-14648, 1996.
Khelef et al., JBC, 273/18:11218-11224, 1998.
Fazio et al., J. Clinical Invest. 107/2:163-171, 2001.
Yang et al., JBC, 276/24:20989-998, 2001.
Seo et al, Circulation, vol. 100, No. 19, Suppl I, pl-612, Abstract No. 3228, 1999.
Becker et al, Arterioscler. Thromb, 14: 1346-1355, 1994.
Pape et al., J. Lipid Research, 36:823-838, 1995.
Sonda et al., JBC, 276/37:34434-34440, 2001.
Anderson, et al., (1998) “Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates,”Journal of Biological Chemistryvol. 273(41):26747-26754.
Cases, et al., (Oct. 9, 1998) “ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase,”Journal of Biological Chemistryvol. 273(41):26755-26764.
Chang, et al., (Dec. 25, 1998) “Recombinant Acyl-CoA:cholesterol Acyltransferase-1 (ACAT-1) Purified to Essential Homogeneity Utilizes Cholesterol in Mixed Micelles or in Vesicles in a Highly Cooperative Manner,”Journal of Biological Chemistryvol. 273(52):35132-35141.
Erickson, et al., (Oct. 1980) “Acyl-Coenzyme A: Cholesterol Acyltransferase in Human Liver. In Vitro Detection and Some Characteristics of the Enzyme,”Metabolismvol. 29(10):991-996.
Farese, (1998) “Acyl CoA: Cholesterol Acyltransferase Genes and Knockout Mice,”Curr Opin Lipidolvol. 9:119-123.
Meiner, et al., (1997) “Tissue Expression Studies on the Mouse acyl-CoA: Cholesterol Acyltransferase Gene (Acact): Findings Supporting the Existence of Multiple Cholesterol Esterfication Enzymes in Mice,”Journal of Lipid Researchvol. 38:1928-1933.
Meiner, et al., (Nov. 1996) “Disruption of the acyl-CoA: Cholesterol Acyltransferase Gene in Mice: Evidence Suggesting Multiple Cholesterol Esterfication Enzymes in Mammals,”Proc. Natl. Acad. Sci. USAvol. 93(24):14041-14046.
Oelkers, et al., (1998) “Characterization of Two Human Genes Encoding Acyl Coenzyme A: Cholesterol Acyltransferase-related Enzymes,”Journal of Biological Chemistryvol. 273(41):26765-26771.
Roark, et al., (1993) “Inhibitors of Acyl-CoA: Cholesterol Acyltransferase (ACAT). 2. Modification of Fatty Acid Anilide ACAT Inhibitors: Bioisoteroc Replacement of the Amide Bond,”J. Med. Chem. vol. 36:1662-1668.
Suckling, (1984-85) “Cholesterol Esterification and Hydrolysis in the Adrenal Cortex- The Role of ACYL-CoA: Cholesterol Acyltransferase,”Endocrine Researchvol. 10(3,4):507-514.
Tabas, et al., (1988) “Acyl Coenzyme A: Cholesterol Acyl Transferase in Macrophages Utilizes a Cellular Pool of Cholesterol Oxidase-accessible Cholesterol as Substrate,”Journal of Biological Researchvol. 263(3):1266-1272.
Uelmen, et al., (1995) “Tissue-Specific Expression and Cholesterol Regulation of Acylcoenzyme A: Cholesterol Acyltransferase (ACAT) in Mice,”Journal of Biological Chemistryvol. 270(44):26192-26201.
Gen Bank Accession No. AF099031 (May 20, 1999), “Homo Sapiens Acyl Co-A: Cholesterol Acyltransferase-2 (ACAT2) mRNA, complete cds.”
Gen Bank Accession No. AA133152 (May 14, 1997), “zk97a05.s1 Soares—pregnant—uterus—NbHPU Homo sapiens cDNA clone IMAGE:490736 3′ similar to TR:G461132 G461132 ACAT-2=Acetyl-COA Acetyltransferase, TCP-1X {3′ Region, Overlapping Region}; contains Alu repetitive element;, mRNA sequence.”
Gen Bank Accession No. AA502423 (Aug. 18, 1997), “ng22d09.s1 NCI—CGAP—Ov2 Homo sapiens cDNA clone IMAGE:930161 similar to TR:G461132 G461132 ACAT-2=Actyl-COA Acetyltransferase, TCP-1X {3′ Region, Overlapping Region} ;, mRNA sequence.”
Gen Bank Accession No. AF078751 (Oct. 15, 1998), “Mus musculus acyl coenzyme A: cholesterol acyltransferase-2 (Acact-2) mRNA, complete cds.”
Gen Bank Accession No. S67969 (Mar. 16, 1994), “Acat-2=acetyl-CoA acetyltransferase, Tcp-1x {3′ region, overlapping region} [mice, Genomic, 370 nt].”
Gen Bank Accession No. AAC78335 (May 20, 1999), “acyl Co-A: cholesterol acyltransferase-2.”
Gen Bank Accession No. AAC64057 (Oct. 7, 1997), “acyl coenzyme A: cholesterol acyltransferase-2.”
DeWitt S. Goodman, “Cholesterol Ester Metabolism”P

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