Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-11-20
1980-07-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548330, A61K 31415, C07D23512
Patent
active
042139937
ABSTRACT:
New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
REFERENCES:
patent: 3318889 (1967-05-01), Bywater et al.
patent: 3849431 (1974-11-01), Gallay et al.
Grantham et al., J. Chem. Soc.(c), 1969, pp. 70-74.
Ferrini Pier G.
Habicht Ernst
Sallmann Alfred
Ciba-Geigy Corporation
Harkaway Natalia
Maitner John J.
Rotman Alan L.
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