Acyl and ester derivatives of 1,3-diazabicyclo[3,3,0]octane

Details Acyl and ester derivatives of 1,3-diazabicyclo[3,3,0]octane Acyl and ester derivatives of 1,3-diazabicyclo[3,3,0]octane

1983-01-13

1986-04-22

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548550, C07D48706

Patent

active

045843872

ABSTRACT:
An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.

REFERENCES:
patent: 4131623 (1978-12-01), Myers
Eliel et al, Jour. Amer. Chem. Soc., vol. 100, No. 5, Mar. 1978, pp. 1614-1616.
Mukaiyama et al, Chemistry Letters, Nov. 1978, 1253-1256.
Beilsteins Handbuch der Organischen Chemie, 4th Edition, 34d Supplement, vol. 8, Part 2, 1969, Springer-Verlag, Berlin, Heidelberg, N.Y., p. 1367, Formula III.
Blumbergs et al, Jour. Org. Chem., vol. 37, No. 8 (1972) 1248-1251.
Wanzlick et al, Chem. Ber., vol. 86 (1953) 1463-1466.
Synthesis, 454-455 (1976).
Tetrahedron Letters, No. 26, 2681-2684 (1972).
Helv. Chim. Acta, 61, 1903-1911 (1978).
Copendium Organic Synthetic Methods, vol. 2, pp. 284-287 (1974).
Tetrahedron Letters, 22, 2855-2858 (1981).
J. Org. Chem., 44, 3598-3599 (1979).
Chemistry Letters, No. 6, 1979, T. Mukaiyama et al., "Versatile Method for the Preparation of Optically Active Alpha-Hydroxy Aldehydes with Desired Configurations", pp. 705-708.
Chemistry Letters, No. 8, 1979, Y. Sakito et al., "Asymmetric Synthesis of Two Enactionmers of Frontalin", pp. 1027-1028.
McKenzie et al, J. Chem. Soc. (London), vol. 121, pp. 1348-1361 (1922).

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