Acyl-1H-1,2,4-triazole derivatives

Details Acyl-1H-1,2,4-triazole derivatives Acyl-1H-1,2,4-triazole derivatives

1979-10-23

1984-07-10

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548262, A61K 3141, C07D24908

Patent

active

044593023

ABSTRACT:
New acyl-1H-1,2,4-triazole derivatives of the formula ##STR1## wherein R may be located on one of the two adjacent nitrogen atoms and may represent hydrogen; a group R.sub.5 -CO wherein R.sub.5 is selected from (C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.2-4)alkynyl, phenyl, phenyl substituted by one to three groups independently selected from halo, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C.sub.1-4)alkylamino, (C.sub.2-4)acylamino and methylenedioxy, benzyl, cinnamyl, amino, (C.sub.1-4)alkylamino, di-(C.sub.1 -C.sub.4)alkylamino, phenylamino, phenylamino wherein the phenyl ring may be substituted by one to three groups independently selected from halo, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C.sub.1-4)alkylamino, (C.sub.2-4)acylamino and methylenedioxy, halo(C.sub.1-4)alkyl, (C.sub.1-4)alkoxy and benzyloxy;

REFERENCES:
patent: 3308131 (1967-03-01), McKusick
patent: 4119635 (1978-10-01), Omodei-Sale et al.
patent: 4154841 (1979-05-01), Wade et al.
Kubota et al., Chem. Pharm. Bull., (Japan), vol. 23, pp. 955-966, (1975).

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