Acyclovir dihydrate sodium salt and the preparation thereof

Details Acyclovir dihydrate sodium salt and the preparation thereof Acyclovir dihydrate sodium salt and the preparation thereof

1997-10-27

2000-03-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318

Patent

active

060404450

ABSTRACT:
9-[(2-Hydroxyethoxy)methyl]guanine (acyclovir) dihydrate sodium salt and the process for the preparation thereof comprising the dissolution of acyclovir monosodium salt in an aqueous medium and the precipitation of the resultant dihydrate sodium salt in an organic solvent.

REFERENCES:
patent: 3819620 (1974-06-01), Dursch
patent: 4504657 (1985-03-01), Bouzard
patent: 4562181 (1985-12-01), Crisp
Physicians Desk Reference, 51st edition, p. 1067, 1997.
European Pharmacopoeia, p. 387, 1997.
Physicians Desk Reference #1 Entry for Zovirax Acyclivor Sodium, 1996.
Physician Desk Reference #2 Entries for Prinivil and Vasotec, 1996.
American Drug Index p. 350, 1976
Aspe, Journal Phar. Sci 84, p. 750, Jun. 1995

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