Acyclic purine phosphonate nucleotide analogs as antiviral agent

Details Acyclic purine phosphonate nucleotide analogs as antiviral agent Acyclic purine phosphonate nucleotide analogs as antiviral agent

1992-07-31

1996-07-02

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

544244, 549555, 558187, 558189, A61K 31675, C07F 96512

Patent

active

055322255

ABSTRACT:
Acyclic purine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. These antiviral agents have the structural formula (Ia) or (Ib) ##STR1## and may be in acid, salt or ester form. Such compounds may also be dehydrated to provide antiviral agents in cyclic form. Pharmaceutical compositions are provided containing the antiviral agents, as is a chiral synthesis which may be used to prepare the agents in enantiomerically pure form or as a racemic mixture.

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Striecher et al., Chemica Scripta 26:179-182 (1986).
Duke et al., Antiviral Research 6:299-308 (1986).

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