Acyclic piperidine derivatives

Details Acyclic piperidine derivatives Acyclic piperidine derivatives

2005-09-27

2005-09-27

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S262000, C546S314000, C546S328000

Reexamination Certificate

active

06949655

ABSTRACT:
A compound having the formula (I):wherein:each R1, R2, R3and R4are independently selected from (C1-C10)-straight or branched alkyl, Ar-substituted- (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or Ar-substituted-(C2-C10)-straight or branched alkenyl or alkynyl; whereinone to two CH2groups of said alkyl, alkenyl, or alkynyl chains in each of R1, R2, R3and R4are optionally and independently replaced with O, S, S(O), S(O), S(O)2, C(O) or N(R5) in a chemically stable arrangement, wherein the CH2group of R1and R2bound directly to said nitrogen cannot be replaced with C(O); orR1and R2taken together form a 4 to 7 membered ring; orR3and R4taken together form a 3 to 7 membered ring; wherein a CH2in either the R1and R2ring system or the R3and R4ring system is independently and optionally replaced with O, C(O), N(R5), S, S(O), S(O)2 in a chemically stable arrangement; orwherein either or both of the R1and R2ring system and the R3and R4ring system is optionally fused with Ar.These compounds are useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising these compounds, and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

REFERENCES:
patent: 2957881 (1960-10-01), Hoffmann et al.
patent: WO 99/55688 (1999-11-01), None
Oda, Ryohei; Katsuragawa, Seiichi; Ito, Yoshihiko; Okano, Masaya, Nippon Kagaku Zasshi, 87(11), 1236-8 (Japanese) 1966, Chemical Abstracts 66:94892.
Shanker, et al., Database Crossfire Beilstein, Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; database accession No. brn 543330, brn 53519, J. Prakt. Chem., 30:10 (1965).

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