Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2006-06-20
2009-10-20
Berch, Mark L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C544S118000, C544S244000, C544S243000, C558S189000, C558S169000, C558S177000, C556S437000
Reexamination Certificate
active
07605147
ABSTRACT:
The present invention relates to an acyclic nucleoside phosphonate derivative represented by the following formula (1):in whichrepresents single bond or double bond, R1, R2, R3, R7and R8are defined herein, Y represents —O—, —S—, —CH(Z)-, ═C(Z)-, —N(Z)-, ═N—, or —SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, C1-C7-aminoalkyl or phenyl, Q represents a group having the following formula:wherein X1, and X2independently of one another represent hydrogen, amino, hydroxy or halogen, or represent C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C1-C5-alkoxy, or represent C6-C10-arylthio which is optionally substituted by nitro, amino, C1-C6-alkyl or C1-C4-alkoxy, or represent C6-C12-arylamino, C1-C7-alkylamino, di(C1-C7-alkyl)amino, C3-C6-cycloalkylamino or a structure ofwherein n denotes an integer of 1 or 2 and Y1represents O, CH2or N—R (R represents C1-C7-alkyl or C6-C12-aryl), which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.
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Cho Dong-Gyu
Cho Seung-Joo
Cho Woo-Young
Choi Jong-Ryoo
Choi Tae-Saeng
Berch Mark L
Birch & Stewart Kolasch & Birch, LLP
LG Life Sciences Ltd.
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