Acyclic nucleoside derivatives

Details Acyclic nucleoside derivatives Acyclic nucleoside derivatives

2003-12-19

2008-10-07

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S263370, C544S276000, C544S277000

Reexamination Certificate

active

07432274

ABSTRACT:
Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula:where one of R1and R2is an amino acid acyl group and the other of R1and R2is a —C(O)C3-C21saturated or monounsaturated, optionally substituted alkyl andR3is OH or H.

REFERENCES:
patent: 5216141 (1993-06-01), Benner
patent: 5216142 (1993-06-01), Horrobin et al.
patent: 5284837 (1994-02-01), Lindborg et al.
patent: 5473063 (1995-12-01), Classon et al.
patent: 5543414 (1996-08-01), Nestor et al.
patent: 5565461 (1996-10-01), Lindborg et al.
patent: 5608064 (1997-03-01), Singh et al.
patent: 5656617 (1997-08-01), Lindborg et al.
patent: 5747473 (1998-05-01), Classon et al.
patent: 5869493 (1999-02-01), Engelhardt et al.
patent: 6255312 (2001-07-01), Engelhardt et al.
patent: 6703394 (2004-03-01), Engelhardt et al.
patent: 19526163 (1996-02-01), None
patent: 0099493 (1984-02-01), None
patent: 0186640 (1986-07-01), None
patent: 0308065 (1989-03-01), None
patent: 0165289 (1989-04-01), None
patent: 0343133 (1989-11-01), None
patent: 0375329 (1990-06-01), None
patent: 0654473 (1995-05-01), None
patent: 0694547 (1996-01-01), None
patent: 0728757 (1996-08-01), None
patent: 0827960 (1998-03-01), None
patent: 85/02845 (1985-07-01), None
patent: 89/03837 (1989-05-01), None
patent: 89/10923 (1989-11-01), None
patent: 93/07163 (1993-04-01), None
patent: 94/22887 (1994-10-01), None
patent: 94/24134 (1994-10-01), None
patent: 95/09855 (1995-04-01), None
patent: 95/22330 (1995-08-01), None
patent: 97/27194 (1997-07-01), None
patent: 97/27195 (1997-07-01), None
patent: 97/27196 (1997-07-01), None
patent: 97/27197 (1997-07-01), None
patent: 97/27198 (1997-07-01), None
patent: 97/30051 (1997-08-01), None
patent: 97/30052 (1997-08-01), None
J.F. Nave et al., “Synthesis, Enzymatic Phosphorylation and Antiviral Activity of Acyclic Dienyl Phosphonate Derivatives of Guanine”, Biorganic & Medical Chemistry Letters 6 179-184 (1996).
S. Halazy et al., “9-(Difluorophosphonalkyl) guanines as a New Class of Multisubstrate Analogue Inhibitors of Purine Nucleoside Phosphorylase”, J. Am. Chem. Soc. vol. 113, pp. 315-317 (1991).
F. Vandendriessche et al., “Synthesis and Antiviral Activity of Acyclic Nucleosides with a 3(S), 5-Dihyroxypentyl or 4(R)-Methoxy-3(S), dihydroxypentyl Side Chain”, J.Med.Chem. vol. 35, No. 8, pp. 1458-1465 (1992).
Benjamin et al., Pharmaceutical Research, 4, No. 2, 120-125 (1987).
Harden et al., J. Med. Chem. 32, 1738-1743 (1989).
Lake-Bakaar et al., Antimicrobial Agents and Chemotherapy, 33, No. 1, 110-112 (1989).
Hodge et al., Antimicrobial Agents and Chemotherapy, 33, No. 10., 1765-1773 (1989).
Terao et al., Chem. Pharm. Bull. 39(3), 823-825 (1991).
Ohsawa et al., Chem. Pharm. Bull. 41(11) 1906-1909 (1993).
Lowe, Antimicrobial Agents and Chemotherapy, 39, No. 8, 1802-1808 (1995).
Kim et al., Bioorganic & Medicinal Chemistry Letters 6, No. 15, 1849-1854 (1996).
M. Perez et al. “Stereocontrolled Synthesis of Phosphonate Derivatives of Tetrahydro-and Dihydro-2H-Pyranyl Nucleosides: The Selectivity of the Ferrier Rearrangement”, Tetrahedron, vol. 6, No. 4, pp. 973-984 (1995).
G.R. Green, “The Effecet of the C-6 Constituent on the Regrioselectivity of N-Alkylation of 2-Aminopurines”, Tetrahedron, vol. 46, No. 19, 99. 6903-6914 (1990).
M. Ashwell, “An Improved Route to Guanines Substituted at N-9”, J. Chem. Soc., Chem, Commun., pp. 955-956 (1990).
“Drug Evaluation Manual,” 1993 (A.M.A) p. 1723.
de Miranda, Antiviral Chem & Chemotherapy, 3(1), 1-8.
de Miranda, “Acyclovir Symposium” in Am. J. Medicine, vol. 73, p. 31.

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