Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-03
1997-09-02
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514419, 514323, 5142335, 544124, 544143, 546175, 5462684, 5462764, 5462774, 548495, 548455, 548159, 548253, 5483051, C07D41314, C07D41312, C07D20920, C07D40312, A61K 31405, A61K 31535, A61K 21455
Patent
active
056631715
ABSTRACT:
The present invention is directed to certain compounds of the general structural formula: ##STR1## wherein R.sub.1, R.sub.1a, R.sub.2a, R.sub.3, R.sub.3a, R.sub.4, R.sub.5, R.sub.6, A, W, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
REFERENCES:
patent: 4411890 (1983-10-01), Momany
patent: 4522824 (1985-06-01), Wagnon et al.
patent: 4658038 (1987-04-01), Tamir et al.
patent: 5324737 (1994-06-01), D'Ambra et al.
McDowell, et al., Proc. Natl. Acad. Sci. USA, 92, 11165-11169 (Nov. 1995) "Growth hormone secretagogues: Characterization, efficacy, and minimal bioactive conformation".
Slide of Presentation on "Genentech Growth Hormone Secretagogues" by Todd Somers, at Serano Symposium on Growth Secretagogues, in St. Petersburg, Florida, Dec. 5-8, 1994.
Smith, et al., Science, "A Nonpeptidyl Growth Hormone Secretagogue", vol. 260, pp. 1640-1643, Jun. 11, 1993.
Chen Meng Hsin
Morriello Gregori J.
Nargund Ravi
Patchett Arthur A.
Yang Lihu
Merck & Co. , Inc.
Rose David L.
Springer David B.
Thies J. Eric
LandOfFree
Acyclic compounds promote release of growth hormone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acyclic compounds promote release of growth hormone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acyclic compounds promote release of growth hormone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-308413