Acute renal injury

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C436S501000, C436S518000, C422S050000, C422S067000, C424S009100

Reexamination Certificate

active

07833732

ABSTRACT:
We disclose a new and useful biomarker for acute kidney injury (i.e., AKI), renal ischemia reperfusion injury (i.e., IRI), ischemic acute kidney injury, and/or ischemic acute tubular necrosis (i.e., ATN). The biomarker is GRO-alpha (i.e., CXCL1, chemokine C-X-C ligand 1, GRO1, GROa, MGSA, MGSA alpha, MGSA-a, NAP-3, SCYB1). We detected the biomarker using a QUANTIKINE® human GRO-alpha immunoassay (Cat. No. DGR00, R & D Systems, Minneapolis, Minn.). In addition, we disclose a method of treating lung damage.

REFERENCES:
patent: 03/082258 (2003-10-01), None
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Molls et al., “Keratinocyte-Derived Chemokine is an Early Biomarker of Ischemic Acute Kidney Injury,” American Journal of Physiology-Renal physiology, 2006, vol. 290, No. 5, pp. F1187-F1193.
Miura et al., “Neutralization of 1-3, 5-13 Groalpha and Macrophage Inflammatory Protein-2 Attenuates Renal Ischemia/Reprefusion Injury,” American Journal of Pathology, 2001, vol. 159, No. 6, pp. 2137-2145.
Leonard et al., “″15-EPI-16-(Para-Fluorophenoxyl)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-EPI-Lipoxin A4, is Protective in Experimental Ischemic Acute Renal Failure,” Journal of the American Society of Nephrology, 2002, vol. 13, No. 6, pp. 1657-1662.

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