Acute phase protein modulating endotoxic activity of lipopolysac

Details Acute phase protein modulating endotoxic activity of lipopolysac Acute phase protein modulating endotoxic activity of lipopolysac

1997-12-15

1999-02-16

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 732, 435 792, 424 149, 424 169, 424 91, 424 9322, G01N 3353, G01N 3352

Patent

active

058719377

ABSTRACT:
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute phase serum, but is substantially absent from normal serum; (b) binds to Gram-negative bacterially secreted lipopolysaccharide in vitro in the serum of the animal treated; (c) retards in vitro binding of the lipopolysaccharide to high density lipoprotein present in the normal serum of the animal host; and (d) immunoreacts with antibodies raised to a polypeptide having the amino acid residue sequence, from left to right and in the direction from amino-terminus to carboxy-terminus, or ##STR1## wherein each of said parenthesized amino acid residues is an alternative to the immediately preceding residue in said sequence.

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Goding et al., Monoclonal Antibodies: Principles and Practice, pp. 70-77.
Tobias et al., J. Exp. Med., 164:777, 1986.

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