ACTR-1, a novel human acyltransferase and uses thereof

Details ACTR-1, a novel human acyltransferase and uses thereof ACTR-1, a novel human acyltransferase and uses thereof

2008-07-02

2010-10-26

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C530S350000

Reexamination Certificate

active

07820403

ABSTRACT:
The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 5888793 (1999-03-01), Corley et al.
patent: 2003/0165831 (2003-09-01), Lee et al.
patent: WO 01/60860 (2001-08-01), None
patent: WO 01/73051 (2001-10-01), None
patent: WO 02/00857 (2002-01-01), None
patent: WO 02/00857 (2002-01-01), None
patent: WO 02/26950 (2002-04-01), None
patent: WO 02/40666 (2002-05-01), None
Hegde et al. Database: EST, Accession No. AW976326, (2000).
Shin et al. “transcriptional regulation of p90 with sequence homology toEscherichia coliglycerol-3-phophate acyltransferase” J. Biol. Chem. 266 (35), 23834-23839 (1991).
Bhat et al. “Rat sy-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the CDNA and expressed protein” Biochim. Biophys. Acta 1439, 415-423 (1999).
Wilkison, W. O. and Bell, R. M., Biochim. Biophys. Acta 1348:3-9 (1997).
Dircks, L. and Sul. H. S., Prog. Lipid Res. 38:461-479 (1999).
Dircks, L. et al., J. Biol. Chem. 274(49):34728-34734 (1999).
Yet, S-F. et al., Biochemistry 32:9486-9491 (1993).
Yet, S-F. et al., Biochemistry 34:7303-7310 (1995).
Yamashita, A. et al., J. Biochem. 122:1-16 (1997).
Lewin, T. M. et al., Biochemistry 38:5764-5771 (1999).
Heath, R. and Rock, C. O., J. Bacteriol. 181(6):1944-1946 (1999).
Schlossman, D. M., and Bell, R. M., J. Biol. Chem. 251(18):5738-5744 (1976).
Zhang, Y. et al., Nature 372:425-432 (1994).
Garg A., Grundy S. M., Ann Intern Med 121:416-422 (1994).
Kuroki S. et al., Lipids 34(8):817-823 (1999).
Elmore, M.A., “Mammalian Lyso Phosphatidic Acid Acyl Transferases,” Research Disclosure, Kenneth Mason Publications, Hampshire, GB, No. 400 (Aug. 1, 1997) pp. 551-553 (XP000726660 ISSN: 0374-4353).

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