Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-09-15
2009-11-10
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S024300, C435S091200
Reexamination Certificate
active
07615342
ABSTRACT:
The present invention concerns novel methods of selecting or matching a sport or sporting event to an individual (e.g. a sprint/power sport or an endurance sport) and predicting athletic performance, the methods involving assessing ACTN3 genotype. In alternative embodiments, training regimens may be optimally designed for athletes by assessing the ACTN3 genotypes. Certain embodiments concern combining the assessment of the ACTN3 genotype with other known fitness-related genes to better assess the athletic potential of an individual. In addition, the genotypic analysis of the ACTN3 gene may be combined with physiological tests, physical measurements and/or psychological assessments to more optimally design a training regimen for an individual athlete.
REFERENCES:
patent: 801274 (1905-10-01), Schulz
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4883750 (1989-11-01), Whiteley et al.
patent: 5206347 (1993-04-01), Ruoslahti et al.
patent: 5279721 (1994-01-01), Schmid
patent: 5919626 (1999-07-01), Shi et al.
patent: 5952174 (1999-09-01), Nikiforov et al.
patent: 0320308 (1993-11-01), None
patent: 0329822 (1994-06-01), None
patent: 2 202328 (1988-09-01), None
patent: WO 88/10315 (1988-12-01), None
patent: WO 89/06700 (1989-07-01), None
patent: WO 89/09284 (1989-10-01), None
North et al, Nature Genetics (1999) vol. 21, pp. 353-354.
Lucia, et alInternational Journal of Sports Medicine(2006) vol. 27, pp. 880-884.
North Nature Genetics (1999) vol. 21 pp. 353-354.
Costill et al Journal of Applied Physiology (1976) vol. 40, pp. 149-153.
Rankinen et al, Medicine in sports and Exercise (2002) pp. 1219-2133.
Voet et al Biochemistry, published 199, p. 78.
Brenner et al (Trends in Genetics (2001) vol. 17, pp. 414-418).
O'Brien et al (Science magazine (1999) vol. 286, pp. 458-462, 479-481.
Pitsiladis et al (Lancet (2005) vol. 366, pp. s16-s17).
Mills et al, Human Molecular Genetics (2001) vol. 10, pp. 1335-1346.
genecards.org/cgi-bin/carddisp.pl?gene=ACTN3&search=actn3&suff=txt, pp. 1-11, Mar. 24, 2007.
Yang, et al, Med. Sci. Sport and Exercise (2005) vol. 37, s42.
Moran et al, European Journal of Human Genetics (2007) vol. 15, pp. 88-93.
Blanchard, Andrew, et al., “The Structure and function of a-actinin,” Journal of Muscle Research and Cell Motility 10, 280-289 (1989).
Beggs, Alan H., et al., “Cloning and Characterization of Two Human Skeletal Muscle a-Actinin Genes Located on Chromosomes 1 and 11” The Journal of Biological Chemistry, vol. 267, No. 13, Issue of May 5, pp. 9281-9288, 1992.
Nave, Rudiger, et al., “Interaction of a-actinin and nebulin In vitro,” Elsevier Science Publishers, vol. 269, No. 1, 163-166, Aug. 1990.
Pap, Iris, et al., “Alpha actinin-CapZ, an anchoring complex for thin filaments in Z-line,” Journal of Muscle Research and Cell Motility 20, pp. 187-197, 1999 Kluwer Academic Publishers.
Salmikangas, Paula, et al., “Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy,” Human Molecular Genetics, 1999, vol. 8, No. 7, pp. 1329-1336 1999 Oxford University Press.
Bellin, Robert M., et al., “Molecular characteristics and Interactions of the Intermediate Filament Protein Synemin,” The Journal of Biologlcal Chemistry, vol. 274, No. 41, Issue of Oct. 8, pp. 29493-29499.
McGregor, Alistair, “Identification of the Vinculin-binding Site in the Cytoskeletal Protein a-actinin” Biochem (1994) 301, pp. 225-233 (Printed in Great Britain).
Hance, Jacqueline, “a-Actinin-2 Is a New Component of the Dystrophin-Glycoprotein Complex” Archihves of Biochemistry and Biophysics, vol. 365, No. 2, May 15, pp. 216-222, 1999.
Otey, Carol A., et al., “Mapping of the a-Actinin Binding Site within the B1 Integrin Cytoplasmic Domain,” The Journal of Biological Chemistry, vol. 268, No. 28, Issue of Oct. 5, pp. 21193-21197.
Fukami, et al., “a-Actinin and Vinculin Are PIP2-binding Proteins Involved in Signaling by Tyrosine Kinase” The Journal of Biological Chemistry, vol. 269, No. 2, Issue of Jan. 14, pp. 1518-1522, 1994.
Shibasaki, Futoshi, et al., “Phosphatidylinositol 3-kinase binds to a-actinin through the p85 subunit” Biochem Journal (1994) 302, pp. 551-557 (Printed In Great Britain).
Pomies, Pascal, et al., “CRP1, a LIM Domain Protein Implicated in Muscle Differentiation, Interacts with a-Actinin” The Journal of Cell Biology, vol. 139, No. 1, Oct. 6, 1997, pp. 157-168.
Pomies, Pascal, et al., “Purification and Characterization of an a-Actinin-Binding PDZ-LiM Protein that is Up-regulated during Muscle Differentiation” The Journal of Biological Chemistry, 1999 the The American Society for Biochemistry and Molecular Biology, Inc., vol. 274, No. 41, Issue of Oct. 8, 1999, pp. 29242-29250.
North, Kathryn, et al., “A common nonsense mutation results in a-actinin-3 deficiency in the general population” 1999 Nature America Inc., vol. 21, Apr. 1999, pp. 353-354.
Nowak, Martin A, et al., “Evolution of genetic redundancy” Letters to Nature vol. 388 Jul. 10, 1997, pp. 167-171.
Chan, Yiu-Mo, et al., “Human Skeletal Muscle-Specific a-Actinin-2 and-3 Isoforms Form Homodimers and Heterodimers in Vitro and In Vivo” Biochemical and Biophysical Research Communications 248, 1998 Article No. RC 988920, pp. 134-139.
Rieder, Mark J., “Sequence variation in the Human Anglotensin Converting Enzyme” Nature Genetics, vol. 22, May 1999, pp. 59-62.
Gayagay, George, et al., “Elite Endurance Athletes and the ACE I allele—the role of Genes in Athletic Performance” Hum Genet (1998) 103 pp. 48-50.
Montgomery, H. E., et al. “Human Gene for Physical Performance” scientific correspondence Nature Macmillan Publishers Ltd 1998 vol. 393 May 21, 1998, pp. 221-222.
Myerson, Saul, et al. “Human Angiotensin I-converting enzyme gene and Endurance Performance” The American Physiological Society 1999 8750-7587/99, pp. 1313-1316.
Nazarov, Igor B., et al. “The angiotensin Converting Enzyme I/D polymorphism in Russian athletes” European Journal of Human Genetics (2001) 9, pp. 797-801.
Woods, David, et al., “Elite Swimmers and the D allele of the ACE I/D Polymorphism” Hum Genet (2001) 108, pp. 230-232.
Meltzoff, A., “Rational Imitation in Preverbal Infants” Nature, vol. 415, Feb. 14, 2002, pp. 755-756.
Rankinen, Tuomo, et al., “The Human Gene Map for Performance and Health-related Fitness Phenotypes: the 2001 update” MSSE Special Report, 0195-9131/02/3408-1219, 2002 by the American College of Sports Medicine.
Perusse, Louis, et al., “The Human Gene Map for Performance and Health-related Fitness Phenotypes: The 2002 Update,” Medicine & Science in Sports & Exercise, the American College of Sports Medicine 0195-9131/03/3508 pp. 1248-1264.
Mills, Michelle, et al., “Differential expression of actin-binding proteins, a-actinin-2 and-3, In different species: implications for the evolution of functional redundancy” Human Molecular Genetics, vol. 10, No. 13, pp. 1335-1346.
Eizema, Karin, et al., “Differential Expression of Equine Myosin Heavy-chain mRNA and Protein Isoforms in a Limb Muscle” vol. 51(9): The Journal of Histochemistry & Cytochemistry, 2003, pp. 1207-1216.
Walker, G. Terrance, et al., “Isothermal in vitro amplification of DNA by a Restriction enzyme/DNA Polymerase System” vol. 89, pp. 392-396, Jan. 1992 Applied Biological Sciences, pp. 392-396.
Kwoh, D. Y., et al., “Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format” Biochemistry, Proc. Natl. Acad. Sci. USA, vol. 86, pp. 1173-1177, Feb. 1989.
Ohara, Osamu, et al., “One-sided Polymerase Chain Reaction: T
Bausch Sarae
Genetic Technologies Limited
Pohnert Steven C
Sheridan & Ross P.C.
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