Activity-dependent neurotrophic factor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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53038824, 5303889, 5303892, 530412, 530416, 530413, 530417, 530399, 530395, 53038823, 530839, 530300, 435 41, C07K 14475, C07K 1622, C07K 100, C07K 114

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active

057672407

ABSTRACT:
The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increase the survival of spinal cord neuron cells, cerebral cortical cells and hippocampal neuron cells which has a molecular weight of 16,000 to 18,000 Daltons as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and a basic pI of about 8.1.

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Brenneman et al. (1987), J. Cell Biol., vol. 104, pp. 1603-1610.
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Waldman (1991), Science vol. 252, pp. 1657-1662.
Goding, Monoclonal Antibodies: Principles and Practice, Chapters 3, pp. 59-93 Academic Press 1986.
Goding, Monoclonal Antibodies: Ratio Principles and practices: Chapter 8, pp. 281-293 Academic Press, 1986.

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