Activity-based probes for protein tyrosine phosphatases

Details Activity-based probes for protein tyrosine phosphatases Activity-based probes for protein tyrosine phosphatases

2005-04-15

2010-06-15

Haq, Shafiqul (Department: 1641)

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

C436S545000, C436S056000, C436S172000, C436S103000, C436S124000, C435S021000, C530S402000

Reexamination Certificate

active

07736911

ABSTRACT:
Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A:Also provided are compositions comprising one of the above compounds covalently bound to a member of the PTP superfamily, methods of labeling a PTP using the compounds, methods of isolating a PTP from a mixture of proteins using the compounds, methods of evaluating whether a substance is an inhibitor of a PTP using the compounds, methods of evaluating the specificity of an inhibitor of a PTP using the compounds, methods of identifying a PTP involved in a disease in a mammal using the compounds, and methods of diagnosing a disease in a mammal using the compounds.

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